The following points highlight the thirteen main principal storage sites for xenobiotics in the living system. The storage sites are: 1. Plasma Proteins 2. Body Fat 3. Liver 4. Kidney 5. Bone 6. Brain and Nervous Tissues 7. Erythrocytes 8. Gonads 9. Respiratory Tract 10. G.I.T. 11. Gall Bladder 12. Spleen 13. Fetus. 1. Plasma Proteins as Storage Depot: Several [...]
Xenobiotics usually pass through a number of cells, such as the stratified epithelium of the skin, the thin cell layers of the lungs or G.I.T., the capillary endothelium, and the cells of target organ or tissue. The cell membrane (plasma membrane) surrounding all these cells are remarkably similar. It is approximately 100 A0 thick with pores of size ranging from [...]
A xenobiotic (toxicant) may be absorbed into an animal via different routes. After absorption it is distributed to different parts of the body and, finally, is available for excretion. Many xenobiotics are known to undergo biotransformation while in the organs and tissues. Biotransformation is also termed metabolic transformation. Definition of Biotransformation: Biotransformation may be defined as "the biologically catalysed conversions [...]